Variable Hepatocellular Vacuolization Associated with Glycogen in Rabbits

Cerebral Glycogen of Rabbits

1. The incorporation of 14C into the brain glycogen of conscious rabbits with labelled glucose, bicarbonate and glutamate as precursors has been studied. 2. Substantial incorporation from all these precursors was demonstrated after an interval of 5hr. from their injection. 3. With [14C]glucose maximal incorporation occurred at about 8hr. from the time of injection. 4. Hydrocortisone led to incr...

Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease.

Hepatocellular adenoma (HCA) is a frequent long-term complication of glycogen storage disease type I (GSD I) and malignant transformation to hepatocellular carcinoma (HCC) is known to occur in some cases. However, the molecular pathogenesis of tumor development in GSD I is unclear. This study was conducted to systematically investigate chromosomal and genetic alterations in HCA associated with ...

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas.

Hepatocellular carcinoma (HCC) most commonly arises from chronic inflammation due to viral infection, as a result of genetic and epigenetic abnormalities. A global picture of epigenetic changes in HCC is lacking. We used methylated CpG island amplification microarrays (MCAMs) to study 6458 CpG islands in HCC and adjacent preneoplastic tissues [chronic hepatitis (CH) or liver cirrhosis (LC)] in ...

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age

Hepatocellular necrosis associated with labetalol.

ambulatory blood pressure (BP) as well as on the magnitude of leg edema of treatments using LER, amlodipine (AML), or hydrochlorothiazide (HCT) in patients with confirmed ambulatory hypertension (daytime systolic BP 135mmHg). A total of 121 eligible patients (66M/55F, mean age of 62.7 7.1 yrs) were randomized to either LER 10 mg (n 39), AML 5 mg (n 39) or HCT 12.5 mg (n 43) for 4 weeks. They we...